Discover the forefront of cancer therapy with “Protein Tyrosine Kinases: From Inhibitors To Useful Drugs.” This comprehensive guide, featuring insights from the pioneers behind Gleevec/Glivec™, delves into the intricate world of PTK inhibitors. Explore cutting-edge drug discovery techniques, including bio- and chemoinformatics, structural biology, and resistance mechanisms, all aimed at developing novel treatments for cancer and other diseases. Learn about the development of selective kinase inhibitors, the role of platelet-derived growth factor antagonists, and the principles of structure-based drug design. Essential reading for researchers and medical professionals seeking to understand the latest advancements in targeted cancer therapies and drug development, this book offers a deep dive into preclinical models and the critical evaluation of on-target vs. off-target effects for kinase inhibitors.