Unlock the fundamental secrets of nucleic acid-metal ion interactions, crucial for modern RNA and DNA function. This comprehensive volume meticulously reviews cutting-edge experimental biophysical studies, providing deep insights into how metal ions sculpt RNA folding pathways and modulate DNA structures. Discover essential details on RNA interference applications, gene expression, and advanced polyanion models. An invaluable resource for researchers in nucleic acids biophysics and molecular biology, it also serves as an accessible introduction for students venturing into this vital scientific domain. Explore the intricate relationship defining biomolecular sciences today.