Explore the cutting-edge research on the molecular biology of Axenfeld-Rieger syndrome (ARS) in ‘Molecular Mechanisms of Axenfeld-Rieger Syndrome’ from The Bookish Owl. This essential medical intelligence unit publication delves into the genetic basis of this heterogeneous group of disorders, including Rieger syndrome and Rieger anomaly. Discover the pivotal role of the PITX2 gene, identified through advanced positional cloning techniques, and understand its function as a homeobox transcription factor. This book details the characteristic eye, tooth, and umbilical defects, as well as other developmental anomalies, and reviews supporting evidence from studies across various model organisms. Essential for researchers and clinicians seeking to understand ARS.